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An assault on a peaceful city of technology by the evil Doctor Man and the Neo Empire Gear awakens an ancient robot, who chooses five humans to awaken into becoming Bioman to face the mechanical invaders.
Doctor Man sends Fara and Psygorn to pursue Mika Koizumi about Bioman, even though she had quit the team while the other members try to win her back onto their side.
When Bio Robo becomes unexpectedly damaged during a battle with a Mecha-Gigan, Shirou tries to get a part needed for repair only to have the powerful Monster standing in his way.
Using Shirou's animal informants, Bioman discovers a Gear plot to replace humans with exploding Mecha Humans to sabotage a super-energy plant.
In order to discourage people from indulging in a rain of coins created by an invisible Mecha Gigan controlled by Monster, Shingo decides to become a bad criminal to get the means to stop it.
Mika's pursuit of a lead when a Mecha Gigant crash lands near a mountain leads her into a confrontation with Fara over a plot connected with a trap by Gear to stop Bio Robo.
When Peebo discovers a letter from a friend from Bio, it inspires Doctor Man to start a plot involving making the robot believe that his friend has returned after 500 years.
As Peebo is forced to give up Bioman's secrets to Gear, the team rescues him as they decide to discover the harsh truth about Joy's ultimate fate.
Ryuuta becomes trapped within the dimension of a supercomputer by twin girl Mecha Humans being used to capture children for Gear.
Doctor Man develops a gun devised of Anti-Bio Particles to destroy the Bio Particles within the Bioman, forcing Mika to make a move that may ultimately prove to be fatal!
After the passing of their teammate, Bioman search for a new Yellow4, all while they're pursued by a mischievous archer who doesn't realize what she's getting into.
Shingo begins to doubt himself when he believes that a Mecha-Human was actually the father of a boy he was trying to save.
Jun tries to figure a way to defeat Gear's newest upgrade on her own while the captain of the Olympic archery tracks her down to find out what happened to her.
When Doctor Man abandons a new Mecha Gigan-controlling super-computer that develops emotions, Hikaru tries to win it over with the concepts of love and empathy.
After being accused by Jun of not doing enough to stop a fungus being distributed by Gear, Hikaru puts it upon herself to find the means to stop their infection plans.
Jun must reach a device that will cause a massive volcanic explosion in 6 hours time, but is distracted by Fara in preventing her from reaching that goal quickly.
